We present an open-source Physics Informed Neural Network environment for simulations of transient phenomena on two-dimensional rectangular domains, with the following features: (1) it is compatible with Google Colab which allows automatic execution on cloud environment; (2) it supports two dimensional time-dependent PDEs; (3) it provides simple interface for definition of the residual loss, boundary condition and initial loss, together with their weights; (4) it support Neumann and Dirichlet boundary conditions; (5) it allows for customizing the number of layers and neurons per layer, as well as for arbitrary activation function; (6) the learning rate and number of epochs are available as parameters; (7) it automatically differentiates PINN with respect to spatial and temporal variables; (8) it provides routines for plotting the convergence (with running average), initial conditions learnt, 2D and 3D snapshots from the simulation and movies (9) it includes a library of problems: (a) non-stationary heat transfer; (b) wave equation modeling a tsunami; (c) atmospheric simulations including thermal inversion; (d) tumor growth simulations.

Physics-informed neural networks (PINNs) have emerged as a powerful tool for solving inverse problems, especially in cases where no complete information about the system is known and scatter measurements are available. This is especially useful in hemodynamics since the boundary information is often difficult to model, and high-quality blood flow measurements are generally hard to obtain. In this work, we use the PINNs methodology for estimating reduced-order model parameters and the full velocity field from scatter 2D noisy measurements in the ascending aorta. The results show stable and accurate parameter estimations when using the method with simulated data, while the velocity reconstruction shows dependence on the measurement quality and the flow pattern complexity. The method allows for solving clinical-relevant inverse problems in hemodynamics and complex coupled physical systems.